Article
Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis.
Proceedings of the National Academy of Sciences of the United States of America - 4 Apr 2017
Mou Haiwei, Moore Jill, Malonia Sunil K, Li Yingxiang, Ozata Deniz M, Hough Soren, Song Chun-Qing, Smith Jordan L, Fischer Andrew, Weng Zhiping, Green Michael R, Xue Wen
Abstract excerpt
Genetic lesions that activate KRAS account for ∼30% of the 1.6 million annual cases of lung cancer. Despite clinical need, KRAS is still undruggable using traditional small-molecule drugs/inhibitors. When oncogenic Kras is suppressed by RNA interference, tumors initially regress but eventually recur and proliferate despite suppression of Kras Here, we show that tumor cells can survive knockout of oncogenic Kras,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.