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Article

Lung-cancer chemoprevention by induction of synthetic lethality in mutant KRAS premalignant cells in vitro and in vivo.

Cancer prevention research (Philadelphia, Pa.) - 1 May 2011

Huang Shaoyi, Ren Xiaoyang, Wang Lai, Zhang Ling, Wu Xiangwei

Abstract excerpt

Lung cancer is the leading cause of cancer death in both men and women in the United States, with a low 5-year survival rate despite improved treatment strategies. These data underscore the great need for effective chemoprevention of this cancer. Mutations and activation of KRAS occur frequently in, and are thought to be a primary driver of the development of, non-small cell lung cancers (NSCLC) of the...

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Identifiers

PMID: 21543344
DOI: 10.1158/1940-6207.CAPR-10-0235

Genes

KRAS
DIABLO
FADD
TNF
XIAP

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