Article
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer.
Cell reports - 1 Dec 2020
Wohlhieter Corrin A, Richards Allison L, Uddin Fathema, Hulton Christopher H, Quintanal-Villalonga Àlvaro, Martin Axel, de Stanchina Elisa, Bhanot Umeshkumar, Asher Marina, Shah Nisargbhai S, Hayatt Omar, Buonocore Darren J, Rekhtman Natasha, Shen Ronglai, Arbour Kathryn C, Donoghue Mark, Poirier John T, Sen Triparna, Rudin Charles M
Abstract excerpt
Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma (LUAD) are associated with aggressive tumor growth, resistance to available therapies, and early death. We investigated the effects of coordinate STK11 and KEAP1 loss by comparing co-mutant with single mutant and wild-type isogenic counterparts in multiple LUAD models. STK11/KEAP1 co-mutation results in significantly elevated...
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