An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.

doi:10.1038/ncomms14294

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Article

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer.

Nature communications - 21 Feb 2017

Vallejo Adrian, Perurena Naiara, Guruceaga Elisabet, Mazur Pawel K, Martinez-Canarias Susana, Zandueta Carolina, Valencia Karmele, Arricibita Andrea, Gwinn Dana, Sayles Leanne C, Chuang Chen-Hua, Guembe Laura, Bailey Peter, Chang David K, Biankin Andrew, Ponz-Sarvise Mariano, Andersen Jesper B, Khatri Purvesh, Bozec Aline, Sweet-Cordero E Alejandro, Sage Julien, Lecanda Fernando, Vicent Silve

Abstract excerpt

KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative therapeutic strategies. Here we report the identification of a common transcriptional signature across mutant KRAS cancers of distinct tissue origin that includes the...

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Identifiers

PMID: 28220783
DOI: 10.1038/ncomms14294
PMCID: PMC5321758

Genes

KRAS
FOSL1
AURKA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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