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Article

FLIP as a therapeutic target in cancer

28 May 2018

Abstract excerpt

One of the classic hallmarks of cancer is disruption of cell death signalling. Inhibition of cell death promotes tumour growth and metastasis, causes resistance to chemo- and radiotherapies as well as targeted agents, and is frequently due to overexpression of antiapoptotic proteins rather than loss of pro-apoptotic effectors. FLIP is a major apoptosis-regulatory protein frequently overexpressed in solid and...

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PMID: 29806737
DOI: 10.1111/febs.14523

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