Article
A dual role for autophagy in a murine model of lung cancer.
Nature communications - 1 Jan 2014
Rao Shuan, Tortola Luigi, Perlot Thomas, Wirnsberger Gerald, Novatchkova Maria, Nitsch Roberto, Sykacek Peter, Frank Lukas, Schramek Daniel, Komnenovic Vukoslav, Sigl Verena, Aumayr Karin, Schmauss Gerald, Fellner Nicole, Handschuh Stephan, Glösmann Martin, Pasierbek Pawel, Schlederer Michaela, Resch Guenter P, Ma Yuting, Yang Heng, Popper Helmuth, Kenner Lukas, Kroemer Guido, Penninger Josef M
Abstract excerpt
Autophagy is a mechanism by which starving cells can control their energy requirements and metabolic states, thus facilitating the survival of cells in stressful environments, in particular in the pathogenesis of cancer. Here we report that tissue-specific inactivation of Atg5, essential for the formation of autophagosomes, markedly impairs the progression of KRas(G12D)-driven lung cancer, resulting in a...
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