Article

Metabolic Origins of Neurotoxic 1-deoxySphingolipids in Type 2 Diabetes

2025-04-28

Abstract excerpt

Type 2 diabetes (T2D) and diabetic peripheral neuropathy (DPN) are associated with disruptions in sphingolipid (SL) metabolism, including an increased formation of neurotoxic 1-deoxysphingolipids (1-deoxySL). Here we report data from an untargeted proteomics, lipidomics and metabolomics profiling in plasma and skin samples of a carefully characterized T2D cohort and age-matched healthy controls. We investigated th...

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Literature Corpus work: 53151549-e17b-5122-81db-d7c4dcbcd61c
DOI: 10.1101/2025.04.25.650588

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