Article

Sphingolipid remodelling in SPT-related neuropathies

2026-04-03

Abstract excerpt

Sphingolipid homeostasis is critical for neuronal structural and functional integrity in the central and peripheral nervous systems. The rate-limiting enzyme of this pathway, serine-palmitoyltransferase (SPT), establishes the metabolic entry point into sphingolipid biosynthesis. Mutations in the SPT subunits, SPTLC1 and SPTLC2 lead to contrasting disease phenotypes in patients, including amyotrophic lateral sclero...

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Literature Corpus work: 8ec11090-55db-55e7-8eff-4e4b0e17a718
DOI: 10.64898/2026.04.01.715856

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