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Article

Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish.

Science (New York, N.Y.) - 4 Nov 2016

Mokalled Mayssa H, Patra Chinmoy, Dickson Amy L, Endo Toyokazu, Stainier Didier Y R, Poss Kenneth D

Abstract excerpt

Unlike mammals, zebrafish efficiently regenerate functional nervous system tissue after major spinal cord injury. Whereas glial scarring presents a roadblock for mammalian spinal cord repair, glial cells in zebrafish form a bridge across severed spinal cord tissue and facilitate regeneration. We performed a genome-wide profiling screen for secreted factors that are up-regulated during zebrafish spinal cord...

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Identifiers

PMID: 27811277
DOI: 10.1126/science.aaf2679
PMCID: PMC5114142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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