Article

Structural determinants in the <i>Staphylococcus aureus</i> derived phenol-soluble modulin α2 peptide required for neutrophil formyl peptide receptor activation

2021-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Highly pathogenic Staphylococcus aureus strains produce phenol-soluble modulins (PSMs), peptides which are formylated N-terminally. Nanomolar concentrations of PSMα2 are recognized by formyl peptide receptor 2 (FPR2), but unlike the prototypic FPR2 agonist WKYMVM, PSMα2 is a biased signaling agonist. A shortened N-terminal PSMα2 variant, consisting of the five N- terminal residues, is selective...

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Literature Corpus work: 4294688b-2e42-5526-b677-b26a706a61aa
DOI: 10.1101/2021.10.26.465826

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