Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Formyl-peptide receptor 2 governs leukocyte influx in local Staphylococcus aureus infections.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2018

Weiss Elisabeth, Hanzelmann Dennis, Fehlhaber Beate, Klos Andreas, von Loewenich Friederike D, Liese Jan, Peschel Andreas, Kretschmer Dorothee

Abstract excerpt

Leukocytes express formyl-peptide receptors (FPRs), which sense microbe-associated molecular pattern (MAMP) molecules, leading to leukocyte chemotaxis and activation. We recently demonstrated that phenol-soluble modulin (PSM) peptides from highly pathogenic Staphylococcus aureus are efficient ligands for the human FPR2. How PSM detection by FPR2 impacts on the course of S. aureus infections has remained unknown....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Toxins
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Degranulation

Share to Leukocytes

Share to Ligands

Share to Neutrophils

Share to Staphylococcal Infections

Share to Staphylococcus aureus

Source

Open in PubMed Open full text

Identifiers

PMID: 28855276
DOI: 10.1096/fj.201700441R
PMCID: PMC5731131

Genes

FPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Formyl-peptide receptor 2 governs leukocyte influx in local Staphylococcus aureus infections.PMID 28855276Read ↗

Structural determinants in the <i>Staphylococcus aureus</i> derived phenol-soluble modulin α2 peptide required for neutrophil formyl peptide receptor activationSemantic proximity Read ↗

Neutrophil chemotaxis by pathogen-associated molecular patterns--formylated peptides are crucial but not the sole neutrophil attractants produced by Staphylococcus aureus.Semantic proximity Read ↗

Signal inhibitory receptor on leukocytes‐1 recognizes bacterial and endogenous amphipathic α‐helical peptidesSemantic proximity Read ↗

Differential requirement of Formyl Peptide Receptor 1 in macrophages and neutrophils in the host defense against Mycobacterium tuberculosis Infection.Semantic proximity Read ↗

Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor.Semantic proximity Read ↗

Dynamic evolution of bacterial ligand recognition by formyl peptide receptorsSemantic proximity Read ↗

Interaction between Staphylococcus Agr virulence and neutrophils regulates pathogen expansion in the skin.Semantic proximity Read ↗

PSMε controls skin commensal CD8 <sup>+</sup> T cell activationSemantic proximity Read ↗

Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruptionSemantic proximity Read ↗

Staphylococcus aureus uses the ArlRS and MgrA cascade to regulate immune evasion during skin infection.Semantic proximity Read ↗

The function of TLR2 during staphylococcal diseasesSemantic proximity Read ↗

Staphylococcus aureus senses human neutrophils via PerR to coordinate the expression of the toxin LukABSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.