Back to search

Article

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants

2021-04-17

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has precipitated multiple variants resistant to therapeutic antibodies. In this study, 12 high-affinity antibodies were generated from convalescent donors in early outbreaks using immune antibody phage display libraries. Of them, two RBD-binding antibodies (F61 and H121) showed high affinity neutralization against SARS-CoV-2, whereas three S2-target anti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4285d603-a5ac-56c7-9764-1385ce1f9553
DOI
10.1101/2021.04.16.440083
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variantsDOI 10.1101/2021.04.16.440083
Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infectionSemantic proximity
Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylacticsSemantic proximity
Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody librariesSemantic proximity
A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variantsSemantic proximity
Rapid selection of a human monoclonal antibody that potently neutralizes SARS-CoV-2 in two animal modelsSemantic proximity
Development of a neutralization monoclonal antibody with a broad neutralizing effect against SARS-CoV-2 variantsSemantic proximity
Fully human single-domain antibodies against SARS-CoV-2Semantic proximity
Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralizationSemantic proximity
Neutralizing Ability of a Single Domain VNAR Antibody: In Vitro Neutralization of SARS-CoV-2 Variants of ConcernSemantic proximity
Broad Neutralization Activity of SARS-CoV-2 Antibody is Achieved by Coordinated Recognition of Virus Vulnerable SiteSemantic proximity
A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2Semantic proximity
Development of a neutralization monoclonal antibody with a broad neutralizing effect against SARS-CoV-2 variantsSemantic proximity
Select a neighboring publication to make it the new centre.