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Development of a neutralization monoclonal antibody with a broad neutralizing effect against SARS-CoV-2 variants

1 Dec 2023

Abstract excerpt

BACKGROUND: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has challenged the effectiveness of current therapeutic regimens. Here, we aimed to develop a potent SARS-CoV-2 antibody with broad neutralizing effect by screening a scFv library with the spike protein receptor-binding domain (RBD) via phage display. METHODS: SKAI-DS84 was identified through phage display, and we...

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PMID: 38041113
DOI: 10.1186/s12985-023-02230-9

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