Article

Contrasting selective pressures shape human pepsinogen A gene copy-number variation across Eurasia

2026-08-21

Abstract excerpt

Diet has repeatedly shaped human genomes, yet adaptation of protein digestion remains poorly understood. Using 1,348 haplotype-resolved assemblies, we reconstructed the structural evolution of the human pepsinogen A (PGA) locus and found a west-to-east increase in copy-number across Eurasia that tracked regional reliance on plant-derived protein. Modern and ancient genomes further revealed a recent selective sweep...

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Literature Corpus work: 4281a8f7-d7ec-5aa3-8fda-ef243a9482b5
DOI: 10.64898/2026.08.17.745382

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