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Leveraging ancient DNA to uncover signals of natural selection in Europe lost due to admixture or drift.

Nature communications - 12 Nov 2024

Pandey Devansh, Harris Mariana, Garud Nandita R, Narasimhan Vagheesh M

Abstract excerpt

Large ancient DNA (aDNA) studies offer the chance to examine genomic changes over time, providing direct insights into human evolution. While recent studies have used time-stratified aDNA for selection scans, most focus on single-locus methods. We conducted a multi-locus genotype scan on 708 samples spanning 7000 years of European history. We show that the G12 statistic, originally designed for unphased diploid...

Topics

DNA, Ancient
Selection, Genetic
Humans
Europe
Genetic Drift
Gene Frequency
Haplotypes
Animals
Lactase
Genetics, Population
Evolution, Molecular
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39532856
DOI: 10.1038/s41467-024-53852-8
PMCID: PMC11557891

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