Article

Structural evolution of trypsinogen gene redundancy confers risk for pancreas diseases

2022-08-09

Abstract excerpt

Trypsin is an important enzyme secreted by the pancreas for digesting proteins. The precursors of major human trypsin are encoded by trypsinogen genes PRSS1 and PRSS2 . Here, we leveraged multi-omic data to study their evolutionary and functional impact. We estimated that the primate trypsinogen gene was duplicated from a single copy to multiple-copy 24-34 million years ago (Mya). Compared to six protein-coding ge...

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Literature Corpus work: a79656f3-29c0-5100-bda7-2404e4eda605
DOI: 10.1101/2022.08.08.22278454

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