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Article

The evolution of pepsinogen C genes in vertebrates: duplication, loss and functional diversification.

PloS one - 1 Jan 2012

Castro Luís Filipe Costa, Lopes-Marques Monica, Gonçalves Odete, Wilson Jonathan Mark

Abstract excerpt

BACKGROUND: Aspartic proteases comprise a large group of enzymes involved in peptide proteolysis. This collection includes prominent enzymes globally categorized as pepsins, which are derived from pepsinogen precursors. Pepsins are involved in gastric digestion, a hallmark of vertebrate physiology. An important member among the pepsinogens is pepsinogen C (Pgc). A particular aspect of Pgc is its apparent single...

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PMID: 22427897
DOI: 10.1371/journal.pone.0032852
PMCID: PMC3298455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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