Article

Ancient Trypsinogen Duplications Shape Pancreatic Disease Risk through Pseudogene Enhancers

2026-02-11

Abstract excerpt

<title>Abstract</title> <p>Understanding how ancient gene duplications influence contemporary disease remains a central challenge in evolutionary medicine. Here we show that primate-specific duplications at the trypsinogen (PRSS1/PRSS2) locus have shaped human pancreatic disease susceptibility through retained regulatory functions of pseudogenes. Comparative genomic analyses reveal tandem duplications arising dur...

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Literature Corpus work: ba0e67c4-bc6d-5a6f-9381-9533e0a61ac6
DOI: 10.21203/rs.3.rs-8799261/v1

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