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Article

Recurrent evolution and selection shape structural diversity at the amylase locus.

Nature - 1 Oct 2024

Bolognini Davide, Halgren Alma, Lou Runyang Nicolas, Raveane Alessandro, Rocha Joana L, Guarracino Andrea, Soranzo Nicole, Chin Chen-Shan, Garrison Erik, Sudmant Peter H

Abstract excerpt

The adoption of agriculture triggered a rapid shift towards starch-rich diets in human populations1. Amylase genes facilitate starch digestion, and increased amylase copy number has been observed in some modern human populations with high-starch intake2, although evidence of recent selection is lacking3,4. Here, using 94 long-read haplotype-resolved assemblies and short-read data from approximately 5,600...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39232174
DOI: 10.1038/s41586-024-07911-1
PMCID: PMC11485256

Genes

AMY2A
AMY2B

Provenance

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