Article
Selective sweep on human amylase genes postdates the split with Neanderthals.
Scientific reports - 17 Nov 2016
Inchley Charlotte E, Larbey Cynthia D A, Shwan Nzar A A, Pagani Luca, Saag Lauri, Antão Tiago, Jacobs Guy, Hudjashov Georgi, Metspalu Ene, Mitt Mario, Eichstaedt Christina A, Malyarchuk Boris, Derenko Miroslava, Wee Joseph, Abdullah Syafiq, Ricaut François-Xavier, Mormina Maru, Mägi Reedik, Villems Richard, Metspalu Mait, Jones Martin K, Armour John A L, Kivisild Toomas
Abstract excerpt
Humans have more copies of amylase genes than other primates. It is still poorly understood, however, when the copy number expansion occurred and whether its spread was enhanced by selection. Here we assess amylase copy numbers in a global sample of 480 high coverage genomes and find that regions flanking the amylase locus show notable depression of genetic diversity both in African and non-African populations....
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