Article

Position-Specific Enrichment Ratio Matrix scores predict antibody variant properties from deep sequencing data

2023-07-11

Abstract excerpt

<h4>Motivation</h4> Deep sequencing of antibody and related protein libraries after phage or yeast-surface display sorting is widely used to identify variants with increased affinity, specificity and/or improvements in key biophysical properties. Conventional approaches for identifying optimal variants typically use the frequencies of observation in enriched libraries or the corresponding enrichment ratios. Howev...

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Literature Corpus work: 4272acc1-d229-58fb-96de-63f25ea582ee
DOI: 10.1101/2023.07.10.548448

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