Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries.

Nature communications - 10 May 2024

Petersen Brian M, Kirby Monica B, Chrispens Karson M, Irvin Olivia M, Strawn Isabell K, Haas Cyrus M, Walker Alexis M, Baumer Zachary T, Ulmer Sophia A, Ayala Edgardo, Rhodes Emily R, Guthmiller Jenna J, Steiner Paul J, Whitehead Timothy A

Abstract excerpt

Antibodies are engineerable quantities in medicine. Learning antibody molecular recognition would enable the in silico design of high affinity binders against nearly any proteinaceous surface. Yet, publicly available experiment antibody sequence-binding datasets may not contain the mutagenic, antigenic, or antibody sequence diversity necessary for deep learning approaches to capture molecular recognition. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Antibody Affinity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens

Share to Complementarity Determining Regions

Share to High-Throughput Nucleotide Sequencing

Share to Immunoglobulin Fab Fragments

Share to Mutation

Share to Protein Engineering

Source

Open in PubMed Open full text

Identifiers

PMID: 38730230
DOI: 10.1038/s41467-024-48072-z
PMCID: PMC11087541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries.PMID 38730230Read ↗

An integrated technology for quantitative wide mutational scanning of human antibody Fab librariesSemantic proximity Read ↗

High-Throughput B Cell Epitope Determination by Next-Generation SequencingSemantic proximity Read ↗

AbDiver – A tool to explore the natural antibody landscape to aid therapeutic designSemantic proximity Read ↗

Deep mutational scanning of an antibody against epidermal growth factor receptor using mammalian cell display and massively parallel pyrosequencingSemantic proximity Read ↗

AbDiver: a tool to explore the natural antibody landscape to aid therapeutic designSemantic proximity Read ↗

AbAgym: a well-curated dataset for the mutational analysis of antibody-antigen complexes.Semantic proximity Read ↗

High-Throughput Machine Learning-Aided Antibody Discovery for Cell Surface AntigensSemantic proximity Read ↗

A synergistic generative-ranking framework for tailored design of therapeutic single-domain antibodiesSemantic proximity Read ↗

The Application of Next Generation Sequencing to the Understanding of Antibody RepertoiresSemantic proximity Read ↗

Advances in antibody discovery from human BCR repertoiresSemantic proximity Read ↗

An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeuticsSemantic proximity Read ↗

mmCSM-AB: guiding rational antibody engineering through multiple point mutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.