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Article

DiGeorge critical region 8 (DGCR8) is a double-cysteine-ligated heme protein.

The Journal of biological chemistry - 13 May 2011

Barr Ian, Smith Aaron T, Senturia Rachel, Chen Yanqiu, Scheidemantle Brooke D, Burstyn Judith N, Guo Feng

Abstract excerpt

All known heme-thiolate proteins ligate the heme iron using one cysteine side chain. We previously found that DiGeorge Critical Region 8 (DGCR8), an essential microRNA processing factor, associates with heme of unknown redox state when overexpressed in Escherichia coli. On the basis of the simila...

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Identifiers

PMID: 21454614
DOI: 10.1074/jbc.M110.180844
PMCID: PMC3089513

Genes

DGCR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21454614-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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