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Article

DiGeorge critical region 8 (DGCR8) is a double-cysteine-ligated heme protein.

The Journal of biological chemistry - 13 May 2011

Barr Ian, Smith Aaron T, Senturia Rachel, Chen Yanqiu, Scheidemantle Brooke D, Burstyn Judith N, Guo Feng

Abstract excerpt

All known heme-thiolate proteins ligate the heme iron using one cysteine side chain. We previously found that DiGeorge Critical Region 8 (DGCR8), an essential microRNA processing factor, associates with heme of unknown redox state when overexpressed in Escherichia coli. On the basis of the similarity of the 450-nm Soret absorption peak of the DGCR8-heme complex to that of cytochrome P450 containing ferrous heme...

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Identifiers

PMID: 21454614
DOI: 10.1074/jbc.M110.180844
PMCID: PMC3089513

Genes

DGCR8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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