Chromatin regulator perturbation causes heme pathway imbalance in yeast and human cells

Abstract excerpt

<title>Abstract</title> <p>Accumulation of fluorescent porphyrins (FLPs), intermediates of heme biosynthesis, occurs under natural and pathological conditions across the tree of life, yet no systematic understanding exists of which perturbations cause it. We conducted a genome-wide yeast screen and surprisingly found that most FLP-accumulating mutants affected chromatin regulation — including histone variant Htz1...

Topics

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• Autophagy in Disease and Therapy
• Binding Sites
• Cancer, Hypoxia, and Metabolism
• Ferroptosis
• Mutagenesis
• Mutation
• NAD
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

22884b82-1eee-5f1a-859a-3f2c317c9f7d

DOI

10.21203/rs.3.rs-10369837/v1