Article

Thiostrepton hijacks pyoverdine receptors to inhibit growth of <i>Pseudomonas aeruginosa</i>

2019-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Pseudomonas aeruginosa is a biofilm-forming opportunistic pathogen and intrinsically resistant to many antibiotics. In a high-throughput screen for molecules that modulate biofilm formation, we discovered that the thiopeptide antibiotic, thiostrepton (TS) - considered inactive against Gram-negative bacteria - stimulated P. aeruginosa biofilm formation in a dose-dependent manner. This phenotype...

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Literature Corpus work: 3ba21b67-2774-538c-8ce8-e0bef7948d44
DOI: 10.1101/567990

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