Article

Pyocyanin disrupts airway regeneration to favor chronic <i>Pseudomonas aeruginosa</i> infection

2026-06-18

Abstract excerpt

During chronic infections, host tissues undergo repeated cycles of injury and repair while being exposed to bacterial products. Although many virulence factors trigger immune responses, whether bacterial metabolites alter tissue architecture by disrupting regenerative programs remains largely unexplored. Here, using a primary-cell-derived human lung microtissue model, we show that the redox-active metabolite pyocy...

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Literature Corpus work: b679f26b-c477-510a-aac9-4d969e59bcc8
DOI: 10.64898/2026.06.15.732350

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