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Article

Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination.

BMC biology - 4 Aug 2022

Lee Bernett, Cyrill Samantha Leeanne, Lee Wendy, Melchiotti Rossella, Andiappan Anand Kumar, Poidinger Michael, Rötzschke Olaf

Abstract excerpt

BACKGROUND: Non-crossover (NCO) refers to a mechanism of homologous recombination in which short tracks of DNA are copied between homologue chromatids. The allelic changes are typically restricted to one or few SNPs, which potentially allow for the gradual adaptation and maturation of haplotypes. It is assumed to be a stochastic process but the analysis of archaic and modern human haplotypes revealed a striking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35927700
DOI: 10.1186/s12915-022-01353-9
PMCID: PMC9354366

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