Article

Post-GWAS functional annotation of the RPTOR locus identifies rs12950541 as a candidate regulatory variant for type 2 diabetes and metabolic traits

2026-04-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Type 2 diabetes (T2D) represents a major global health burden, with over 700 GWAS loci identified. Translation to biological mechanisms remains challenging. This study employs systematic post-GWAS functional annotation to characterize the RPTOR locus, encoding Raptor, a scaffold protein critical for mTORC1 signaling and beta-cell function. <h4>Methods</h4> We analyzed 31 GW...

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Literature Corpus work: 422b4e10-60c0-57b1-98ec-62dabdf0bb2f
DOI: 10.64898/2026.04.26.720864

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Post-GWAS functional annotation of the RPTOR locus identifies rs12950541 as a candidate regulatory variant for type 2 diabetes and metabolic traitsDOI 10.64898/2026.04.26.720864Read

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