A cross-platform approach identifies genetic regulators of human metabolism and health.

doi:10.1038/s41588-020-00751-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A cross-platform approach identifies genetic regulators of human metabolism and health.

Nature genetics - 1 Jan 2021

Lotta Luca A, Pietzner Maik, Stewart Isobel D, Wittemans Laura B L, Li Chen, Bonelli Roberto, Raffler Johannes, Biggs Emma K, Oliver-Williams Clare, Auyeung Victoria P W, Luan Jian'an, Wheeler Eleanor, Paige Ellie, Surendran Praveen, Michelotti Gregory A, Scott Robert A, Burgess Stephen, Zuber Verena, Sanderson Eleanor, Koulman Albert, Imamura Fumiaki, Forouhi Nita G, Khaw Kay-Tee, Griffin Julian L, Wood Angela M, Kastenmüller Gabi, Danesh John, Butterworth Adam S, Gribble Fiona M, Reimann Frank, Bahlo Melanie, Fauman Eric, Wareham Nicholas J, Langenberg Claudia

Abstract excerpt

In cross-platform analyses of 174 metabolites, we identify 499 associations (P < 4.9 × 10-10) characterized by pleiotropy, allelic heterogeneity, large and nonlinear effects and enrichment for nonsynonymous variation. We identify a signal at GLP2R (p.Asp470Asn) shared among higher citrulline levels, body mass index, fasting glucose-dependent insulinotropic peptide and type 2 diabetes, with β-arrestin signaling as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eye Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Pleiotropy

Share to Glycine

Share to Health

Share to Metabolism

Share to Metabolism, Inborn Errors

Share to Metabolome

Share to Sample Size

Source

Open in PubMed Open full text

Identifiers

PMID: 33414548
DOI: 10.1038/s41588-020-00751-5
PMCID: PMC7612925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A cross-platform approach identifies genetic regulators of human metabolism and health.PMID 33414548Read ↗

Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomesSemantic proximity Read ↗

Analysis of whole genome sequencing and plasma metabolomics unveil genetic determinants and clinical implications for human health.Semantic proximity Read ↗

A genetic map of human metabolism across the allele frequency spectrumSemantic proximity Read ↗

Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging.Semantic proximity Read ↗

Shared genetic regulatory networks for cardiovascular disease and type 2 diabetes in multiple populations of diverse ethnicities in the United States.Semantic proximity Read ↗

Rare and common genetic determinants of metabolic individuality and their effects on human health.Semantic proximity Read ↗

Gaining insight into metabolic diseases from human genetic discoveries.Semantic proximity Read ↗

Convergent human genetic evidence implicates serine biosynthesis in diabetic peripheral neuropathySemantic proximity Read ↗

Unique genetic architecture of CSF and brain metabolites pinpoints the novel targets for the traits of human wellnessSemantic proximity Read ↗

Genome-wide association study for circulating metabolic traits in 619,372 individualsSemantic proximity Read ↗

From omics to AI —mapping the pathogenic pathways in type 2 diabetesSemantic proximity Read ↗

Genetics of human metabolism: an update.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.