Article
From genetic association to molecular mechanism.
Current diabetes reports - 1 Dec 2010
van de Bunt Martijn, Gloyn Anna L
Abstract excerpt
Over the past 3 years, there has been a dramatic increase in the number of confirmed type 2 diabetes (T2D) susceptibility loci, most arising through the implementation of genome-wide association studies (GWAS). However, progress toward the understanding of disease mechanisms has been slowed by modest effect sizes and the fact that most GWAS signals map away from coding sequence: the presumption is that their...
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