Article

Anlotinib suppresses MLL-rearranged acute myeloid leukemia cell growth through inhibiting SETD1A/AKT-mediated DNA damage response

2020-03-11

Abstract excerpt

<h4>Background: </h4> Leukemias driven by chromosomal translocation of the mixed-lineage leukemia gene (MLL) are highly prevalent in hematological malignancy. The poor survival rate and lack of an effective targeted therapy for patients with MLL-rearranged (MLL-r) leukemias emphasize an urgent need for improved knowledge and novel therapeutic approaches for these malignancies. In this study, we investigated the po...

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Literature Corpus work: 63d61269-dd77-52b9-b4a5-0f346e2899e9
DOI: 10.21203/rs.3.rs-16791/v1

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