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MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance

27 Nov 2021

Abstract excerpt

Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential of breast cancer cells. However, the functional role of MLK4 in resistance to chemotherapy has not been investigated so far. Here, we demonstrate that MLK4 promotes...

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PMID: 34839359
DOI: 10.1038/s41419-021-04405-0

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