Article

Omics analysis reveals striking effects of progesterone receptor on mitochondria and mitochondria-mediated apoptosis independent of caspases in Breast Cancer cells

2025-03-07

Abstract excerpt

The role of progesterone receptor (PR) in breast cancer remains controversial with conflicting reports from clinical and laboratory studies. To address these discrepancies, we conducted an integrated omics analysis of effects of agonist-activated PR in MCF-7 cells with elevated PR expression. PR agonist R5020 exerted strong antiproliferative and proapoptotic effects in these cells. Quantitative proteomics identifi...

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Literature Corpus work: 71684fa2-4300-5310-9e6b-774bc8d1cf86
DOI: 10.1101/2025.03.06.641096

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