Article

Lactate-dependent metabolic rewiring is associated with CD163 <sup>+</sup> macrophage polarization in human pyelonephritis

2026-04-13

Abstract excerpt

Chronic pyelonephritis is characterized by persistent bacterial infection of the kidney and a dysregulated immune response that promotes disease progression. Macrophages are central regulators of antibacterial immunity in the urinary tract. However, the mechanisms underlying their functional reprogramming in chronic infection remain poorly understood. Here, we identify lactate as a key metabolic determinant of mac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 420198b6-ff25-556b-939b-3f6f0eb36b68
DOI: 10.64898/2026.04.09.717269

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lactate-dependent metabolic rewiring is associated with CD163 <sup>+</sup> macrophage polarization in human pyelonephritisDOI 10.64898/2026.04.09.717269Read

Reduced lactylation-regulator expression coupled with glycolytic activation marks an immunometabolic state associated with clinical stratification in sepsisSemantic proximity Read

Epigenetic Modulation by Lactylation in Sepsis: Linking Metabolism to Immune DysfunctionSemantic proximity Read

Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylationSemantic proximity Read

Host-secreted lactate during respiratory viral infection diminishes macrophage antibacterial activity through metabolic reprogrammingSemantic proximity Read

Role of lactylation-induced macrophage failed phenotypic switching in sustaining inflammation of diabetic wounds.Semantic proximity Read

Dissecting Metabolic Landscape of Alveolar MacrophageSemantic proximity Read

Use of integrated metabolomics, transcriptomics, and signal protein profile to characterize the effector function and associated metabotype of polarized macrophage phenotypes.Semantic proximity Read

Reprogramming of macrophages employing gene regulatory and metabolic network models.Semantic proximity Read

Metabolic influence on macrophage polarization and pathogenesisSemantic proximity Read

A Comprehensive High-Efficiency Protocol for Isolation, Culture, Polarization, and Glycolytic Characterization of Bone Marrow-Derived Macrophages.Semantic proximity Read

Lactate and Lactylation in Sepsis: A Comprehensive ReviewSemantic proximity Read

LDHA-Dependent Aerobic Glycolysis Shapes Pro-fibrotic Myeloid Cell Fate through Histone LactylationSemantic proximity Read