Article

Differential chromatin response to retinoic acid in neuroblastoma according to type of <i>ATRX</i> mutation

2025-07-18

Abstract excerpt

<h4>ABSTRACT</h4> Neuroblastoma is a childhood cancer, arising in the developing sympathetic nervous system. Differentiation therapy with 13-cis-retinoic acid (RA) is routinely given to children with high-risk neuroblastoma in the minimal residual disease setting to prevent relapse, however there is little understanding of which patients benefit from RA therapy. ATRX alterations are identified in 10% of high-risk...

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Literature Corpus work: 42019167-cfd5-5efb-91bd-a3d9b48b32da
DOI: 10.1101/2025.07.14.664731

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