Article

Two opposing gene expression patterns within <i>ATRX</i> aberrant neuroblastoma

2022-10-26

Abstract excerpt

Neuroblastoma is the most common extracranial solid tumor in children. A subgroup of high-risk patients is characterized by aberrations in the chromatin remodeller ATRX that is encoded by 35 exons. In contrast to other pediatric cancer where ATRX point mutations are most frequent, multi-exon deletions (MEDs) are the most frequent type of ATRX aberrations in neuroblastoma. Of these MEDs 75% are predicted to produ...

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Literature Corpus work: 273fe166-990c-507d-818a-a15e2e614172
DOI: 10.1101/2022.10.25.513663

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