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Article

PBX1 Is a Favorable Prognostic Biomarker as It Modulates 13- <i>cis</i> Retinoic Acid–Mediated Differentiation in Neuroblastoma

20 Jun 2014

Abstract excerpt

PURPOSE: Neuroblastoma is an embryonic childhood cancer with high mortality. 13-cis retinoic acid (13-cisRA) improves survival for some patients, but many recur, suggesting clinical resistance. The mechanism of resistance and the normal differentiation pathway are poorly understood. Three-amino-acid loop extension (TALE) family genes are master regulators of differentiation. Because retinoids promote...

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PMID: 24947929
DOI: 10.1158/1078-0432.ccr-13-1486

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