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Article

Mutational spectrum of ATRX aberrations in neuroblastoma and associated patient and tumor characteristics.

Cancer science - 1 Jun 2022

van Gerven Michael R, Bozsaky Eva, Matser Yvette A H, Vosseberg Julian, Taschner-Mandl Sabine, Koster Jan, Tytgat Godelieve A M, Molenaar Jan J, van den Boogaard Marlinde

Abstract excerpt

Neuroblastoma is the most common extracranial solid tumor in children. The chromatin remodeler ATRX is frequently mutated in high-risk patients with a poor prognosis. Although many studies have reported ATRX aberrations and the associated clinical characteristics in neuroblastoma, a comprehensive overview is currently lacking. In this study, we extensively characterize the mutational spectrum of ATRX aberrations...

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Identifiers

PMID: 35384159
DOI: 10.1111/cas.15363
PMCID: PMC9207354

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