Article

A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells

2024-05-05

Abstract excerpt

<h4>ABSTRACT</h4> The transformative potential of gene editing technologies hinges on the development of safe and effective delivery methods. In this study, we developed a temperature-sensitive and interferon-silent Sendai virus (ts SeV) as a novel delivery vector for CRISPR-Cas9 and for efficient gene editing in sensitive human cell types without inducing IFN responses. ts SeV demonstrates unprecedented transduc...

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Literature Corpus work: 78c2b238-3c80-517e-ba55-300c9a84b673
DOI: 10.1101/2024.05.03.592383

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