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Human T cells employ conserved AU‐rich elements to fine‐tune IFN‐γ production

29 Feb 2020

Abstract excerpt

T cell responses are critical in combatting infections and tumors. The pro-inflammatory cytokine IFN-γ is a key effector molecule herein. We recently showed that in murine T cells the production of IFN-γ is tightly regulated through adenylate uridylate-rich elements (AREs) that are located in the 3' untranslated region (UTR) of the Ifng mRNA molecule. Loss of AREs resulted in prolonged cytokine production in...

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PMID: 32112565
DOI: 10.1002/eji.201948458

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