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Article

Targeted Deep Sequencing of Bladder Tumors Reveals Novel Associations between Cancer Gene Mutations and Mutational Signatures with Major Risk Factors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2021

Koutros Stella, Rao Nina, Moore Lee E, Nickerson Michael L, Lee Donghyuk, Zhu Bin, Pardo Larissa A, Baris Dalsu, Schwenn Molly, Johnson Alison, Jones Kristine, Garcia-Closas Montserrat, Prokunina-Olsson Ludmila, Silverman Debra T, Rothman Nathaniel, Dean Michael

Abstract excerpt

PURPOSE: Exome- and whole-genome sequencing of muscle-invasive bladder cancer has revealed important insights into the molecular landscape; however, there are few studies of non-muscle-invasive bladder cancer with detailed risk factor information. EXPERIMENTAL DESIGN: We examined the relationship between smoking and other bladder cancer risk factors and somatic mutations and mutational signatures in bladder...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33849962
DOI: 10.1158/1078-0432.CCR-20-4419
PMCID: PMC8254772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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