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RB1 Mutations Induce Smoking-Related Bladder Cancer by Modulating the Cytochrome P450 Pathway.

Environmental toxicology - 1 Dec 2024

Mao Zhenguang, Gao Fang, Sun Tuo, Xiao Yi, Wu Jiajin, Xiao Yanping, Chu Haiyan, Wu Dongmei, Du Mulong, Zheng Rui, Zhang Zhengdong

Abstract excerpt

Cigarette smoking causes multiple cancers by directly influencing mutation burden of driver mutations. However, the mechanism between somatic mutation caused by cigarette smoking and bladder tumorigenesis remains elusive. Smoking-related mutation profile of bladder cancer was characterized by The Cancer Genome Atlas cohort. Integraticve OncoGenomics database was utilized to detect the smoking-related driver...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39239764
DOI: 10.1002/tox.24409

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