Article

ANCHOR: haplotype-aware allelic and isoform inference from single-cell long-read RNA sequencing with de novo variant calling

2026-06-11

Abstract excerpt

Long-read RNA sequencing enables haplotype– and isoform-resolved allelic analysis of transcriptomes, yet extending this capability to single cells and distinct cell types remains computationally challenging due to sparse coverage, sequencing errors, incomplete variant information, and reference-biased transcript assignment. Here we present ANCHOR, a haplotype-aware framework for single-cell long-read RNA sequencin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cd81538d-8c06-575e-97dc-f5c1937c85a3
DOI: 10.64898/2026.06.08.730656

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ANCHOR: haplotype-aware allelic and isoform inference from single-cell long-read RNA sequencing with de novo variant callingDOI 10.64898/2026.06.08.730656Read

Revealing allele-specific gene expression by single-cell transcriptomics.Semantic proximity Read

LongAllele: a joint inference framework for allele-specific analysis on long-read bulk and single-cell RNA sequencingSemantic proximity Read

scphaser: haplotype inference using single-cell RNA-seq data.Semantic proximity Read

Detection of Imprinted Genes by Single-Cell Allele-Specific Gene Expression.Semantic proximity Read

Single-cell RNA counting at allele- and isoform-resolution using Smart-seq3Semantic proximity Read

Long-read whole-genome sequencing-based concurrent haplotyping and aneuploidy profiling of single cellsSemantic proximity Read

Functional phenotyping of genomic variants using joint multiomic single-cell DNA-RNA sequencing.Semantic proximity Read

Single-cell RNA counting at allele and isoform resolution using Smart-seq3.Semantic proximity Read

Targeted long-read RNA sequencing for rare disease diagnosis and variant interpretation.Semantic proximity Read

Hierarchical analysis of RNA-seq reads improves the accuracy of allele-specific expression.Semantic proximity Read

Rare Variant Phasing and Haplotypic Expression from RNA-Sequencing with phASERSemantic proximity Read