Article
NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.
Cell - 5 Aug 2021
Allouche Jennifer, Rachmin Inbal, Adhikari Kaustubh, Pardo Luba M, Lee Ju Hee, McConnell Alicia M, Kato Shinichiro, Fan Shaohua, Kawakami Akinori, Suita Yusuke, Wakamatsu Kazumasa, Igras Vivien, Zhang Jianming, Navarro Paula P, Lugo Camila Makhlouta, Noonan Haley R, Christie Kathleen A, Itin Kaspar, Mujahid Nisma, Lo Jennifer A, Won Chong Hyun, Evans Conor L, Weng Qing Yu, Wang Hequn, Osseiran Sam, Lovas Alyssa, Németh István, Cozzio Antonio, Navarini Alexander A, Hsiao Jennifer J, Nguyen Nhu, Kemény Lajos V, Iliopoulos Othon, Berking Carola, Ruzicka Thomas, Gonzalez-José Rolando, Bortolini Maria-Cátira, Canizales-Quinteros Samuel, Acuna-Alonso Victor, Gallo Carla, Poletti Giovanni, Bedoya Gabriel, Rothhammer Francisco, Ito Shosuke, Schiaffino Maria Vittoria, Chao Luke H, Kleinstiver Benjamin P, Tishkoff Sarah, Zon Leonard I, Nijsten Tamar, Ruiz-Linares Andrés, Fisher David E, Roider Elisabeth
Abstract excerpt
Ultraviolet (UV) light and incompletely understood genetic and epigenetic variations determine skin color. Here we describe an UV- and microphthalmia-associated transcription factor (MITF)-independent mechanism of skin pigmentation. Targeting the mitochondrial redox-regulating enzyme nicotinamide nucleotide transhydrogenase (NNT) resulted in cellular redox changes that affect tyrosinase degradation. These changes...
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