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Lighting a path to pigmentation: mechanisms of MITF induction by UV

23 Sept 2010

Abstract excerpt

While sunlight is important for life, ultraviolet radiation (UVR) can have harmful and mutagenic effects. This duality is particularly relevant to human skin, in which UVR both participates in evolutionarily important photochemical reactions yet may act as a potential carcinogen. UVR can upregulate production of melanin, the "tanning response" that serves a photoprotective function. This genetic program is...

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PMID: 20973930
DOI: 10.1111/j.1755-148x.2010.00775.x

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