Article

Evaluating codon optimization strategies for mammalian glycoprotein production with an open-source expression vector

2026-03-20

Abstract excerpt

Efficient production of human proteins for the development of tool compounds and biologics depends on a detailed understanding of the protein expression machinery in mammalian cells. Codon optimization is widely believed to enhance protein yield, yet its impact in homologous mammalian systems remains poorly defined. Here, we systematically compare five codon usage strategies reflecting common assumptions about rar...

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Literature Corpus work: 418dce98-e55e-53b6-aebc-1b982367ec6a
DOI: 10.64898/2026.03.18.712111

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