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Optimizing Bispecific Antibody Expression via Multi-Omics Analysis and Vector Redesign

2025-11-12

Abstract excerpt

Bispecific antibodies are a growing class of therapeutics that simultaneously engage two targets. However, their complex molecular structures pose challenges for production in Chinese hamster ovary cells, the current industry standard for biologics manufacturing. Here we present a case study of three IgG-scFv format bsAbs expressed in CHO cells, in which one candidate exhibited markedly lower titers despite high s...

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Literature Corpus work
2efadedd-eea2-587c-8477-1b2594cc0d3c
DOI
10.1101/2025.11.10.687454
Open publication

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Optimizing Bispecific Antibody Expression via Multi-Omics Analysis and Vector RedesignDOI 10.1101/2025.11.10.687454
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