Article

Structural bioinformatics predicts that the Retinitis Pigmentosa-28 protein of unknown function FAM161A is a homologue of the microtubule nucleation factor Tpx2

2020-08-27

Abstract excerpt

<h4>Background: </h4> FAM161A is a microtubule-associated protein conserved widely across eukaryotes, which is mutated in the inherited blinding disease Retinitis Pigmentosa-28. FAM161A is also a centrosomal protein, being a core component of a complex that forms an internal skeleton of centrioles. Despite these observations about the importance of FAM161A, current techniques used to examine its sequence reveal no...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41893cee-ac46-5dc5-8ea6-3d6596492b11
DOI: 10.12688/f1000research.25870.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural bioinformatics predicts that the Retinitis Pigmentosa-28 protein of unknown function FAM161A is a homologue of the microtubule nucleation factor Tpx2DOI 10.12688/f1000research.25870.1Read

The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association.Semantic proximity Read

DHX16-Associated Neuromuscular Oculoauditory Syndrome: A Novel Case.Semantic proximity Read

FAM162A is Crucial for Mitochondrial Structure, Dynamics, and Bioenergetics, Driving Cellular Protection and LongevitySemantic proximity Read

Missense variants in KATNA1 alter microtubule dynamics and underlie dominant macular dystrophySemantic proximity Read

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-bindingSemantic proximity Read

Role of α-tubulin helix 11’ in heterodimer conformation and microtubule dynamicsSemantic proximity Read

Integrative modeling reveals the molecular architecture of the Intraflagellar Transport A (IFT-A) complexSemantic proximity Read

A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 is linked to neurodevelopmental disordersSemantic proximity Read

The trimeric structures of the extracellular domains of FAM171A1 and FAM171A2 neuronal proteins belong to a novel structural superfamilySemantic proximity Read

The intrinsically disordered protein glue of myelin: Linking AlphaFold2 predictions to experimental dataSemantic proximity Read

Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration.Semantic proximity Read

The Armadillo Repeat Protein PF16 Is Essential for Flagellar Structure and Function in Plasmodium Male GametesSemantic proximity Read