Article
The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association.
Human molecular genetics - 1 Nov 2012
Zach Frank, Grassmann Felix, Langmann Thomas, Sorusch Nasrin, Wolfrum Uwe, Stöhr Heidi
Abstract excerpt
Loss-of-function mutations in the gene encoding FAM161A were recently discovered as the cause for RP28, an autosomal recessive form of retinitis pigmentosa. To initiate the characterization of the cellular role of FAM161A in the retina, we focused on its subcellular localization and conducted in vitro studies to identify FAM161A-interacting proteins and associated cellular structures. Immunohistochemistry...
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