Article
Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration.
Human molecular genetics - 1 Oct 2014
Karlstetter Marcus, Sorusch Nasrin, Caramoy Albert, Dannhausen Katharina, Aslanidis Alexander, Fauser Sascha, Boesl Michael R, Nagel-Wolfrum Kerstin, Tamm Ernst R, Jägle Herbert, Stoehr Heidi, Wolfrum Uwe, Langmann Thomas
Abstract excerpt
Mutations in the FAM161A gene were previously identified as the cause for autosomal-recessive retinitis pigmentosa 28. To study the effects of Fam161a dysfunction in vivo, we generated gene-trapped Fam161a(GT/GT) mice with a disruption of its C-terminal domain essential for protein-protein interactions. We confirmed the absence of the full-length Fam161a protein in the retina of Fam161a(GT/GT) mice using western...
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